Bangladesh is one of the high-burden countries of drug-resistant tuberculosis (TB) in the world. Only early diagnosis and proper selection of anti-tubercular treatment (ATT) combat the crisis. The study aims to determine M. tuberculosis resistance and sensitivity pattern in the Dhaka South City Corporation (DSCC) Area.
A cross-sectional observational study designed to determine the M. tuberculosis résistance and sensitivity pattern with Xpert XDR cartridge assay at RTRL, Shamoli. The potential drug resistance TB patients go for Xpert XDR assay, a molecular diagnostic test to determine the M. tuberculosis resistance and sensitivity pattern.
One hundred nine potential drug resistance TB patients Xpert XDR assay was done. The result shows that working-class male of productive age suffers more. DR-TB presumptive age group among people of 35-44 years of age suffer more for DR-TB. It was 24 (22%), and followed by people 25-43 years of age. They were 20 (18.3%). The elderly people also suffered more and were above 65 years of age. They were 14 (12.8%).
|
Age Group |
|||||
|
|
Frequency |
Percent |
Valid Percent |
Cumulative Percent |
|
|
Valid |
5-14 |
2 |
1.8 |
1.9 |
1.9 |
|
15-24 |
21 |
19.3 |
20.0 |
21.9 |
|
|
25-34 |
20 |
18.3 |
19.0 |
41.0 |
|
|
35-44 |
24 |
22.0 |
22.9 |
63.8 |
|
|
45-54 |
13 |
11.9 |
12.4 |
76.2 |
|
|
55-64 |
11 |
10.1 |
10.5 |
86.7 |
|
|
>65 |
14 |
12.8 |
13.3 |
100.0 |
|
|
Total |
105 |
96.3 |
100.0 |
|
|
|
Missing |
System |
4 |
3.7 |
|
|
|
Total |
109 |
100.0 |
|
|
|
DR-TB presumptive resistance and sensitivity pattern. Among 109 XDR assays, INH resistance was 25 (22.9%), Fluoroquinolone resistance was 3 (2.6%), and All MDR-TB were sensitive in 64 (58.7%). M. tuberculosis was not detected among 10 (9.2%).
|
Resistance and Sensitivity |
|||||
|
|
Frequency |
Percent |
Valid Percent |
Cumulative Percent |
|
|
Valid |
INH |
25 |
22.9 |
23.6 |
23.6 |
|
RIF |
4 |
3.7 |
3.8 |
27.4 |
|
|
FLQ |
3 |
2.8 |
2.8 |
30.2 |
|
|
Sanative |
64 |
58.7 |
60.4 |
90.6 |
|
|
No Mtb |
10 |
9.2 |
9.4 |
100.0 |
|
|
Total |
106 |
97.2 |
100.0 |
|
|
|
Missing |
System |
3 |
2.8 |
|
|
|
Total |
109 |
100.0 |
|
|
|
Early diagnosis and proper selection of anti-tubercular treatment (ATT) for drug resistance TB (DR-TB) is mandatory. It can be achieved with rapid molecular drug sensitivity testing and administering all oral shorter treatment regimens (SOTR) for drug-resistant TB patients.
Hasina Akhter1, Syed Sakhawat Hussain2 , Ahmed Parvez Zabeen3
1Associate Professor, Department of Microbiology, Bangladesh Dental College, Dhaka, 2Professor Department of Biochemistry, Parkview Medical College, Sylhet, 3Dr. Ahmed Parvez Zabeen, Divisional Tuberculosis (TB) Expert, National Tuberculosis Control Program (NTP), Bangladesh
Parkview Medical Journal
An official Journal of Parkview Medical College, Sylhet, Bnagladesh
No comments:
Post a Comment